Browsing by Author "Ibragimov, Ruslan"

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    Analysis of the Impact of Human Papillomavirus Type 5 E2 Serine 255 Phosphorylation on the Viral Genome Replication and E2 Protein Stability
    (2021) Ibragimov, Ruslan
    Human papillomaviruses (HPVs) are associated with the number of diseases from genital warts to cancer. While vaccination grants immunity to the wide range of HPV strains, it is important to develop effective treatment strategies to counter already established infections in order to prevent the egress of new strains of the virus. E2 is one of the most promising targets for development of therapeutic agents against the established HPV infections and, as many other proteins, it undergoes post-translational modifications changing the properties and the functions of this protein. This work is focused on investigating the effects of the phosphorylation at Serine 255 residue on the stability of HPV type 5 E2 protein and replication of the viral genome. The results of this work can benefit the projects focused on the treatment of HPV infection through the disruption of E2 functions and synthesis.
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    Identification of inhibitors of the Human Papillomavirus type 5 replication using high-throughput screening and machine learning
    (Tartu Ülikool, 2023) Ibragimov, Ruslan; Piirsoo, Marko, juhendaja; Piirsoo, Alla, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Tehnoloogiainstituut
    Human papillomaviruses (HPVs) have been known to cause a wide variety of health complications from warts to cancer. Although vaccination against several high-risk types of HPVs is available, there is currently no treatment method that would target already established infections. The focus of this study is to perform high-throughput screening of 1584 randomly selected chemicals in order to identify potential inhibitors of the HPV type 5 replication, and then use machine learning to predict interactions between those compounds and proteins expressed in basal keratinocytes, the only cell type that supports HPV replication. At the end of this study, several potential inhibitors were discovered and connections were made to proteins and pathways absolutely necessary for the replication of the viral genome or occurrence of the cancer.