Browsing by Author "Mammadova, Sabina"

Filter results by typing the first few letters
Now showing 1 - 1 of 1
  • Thumbnail Image
    Item
    HPV L2 protein derived endosomal escape enhancers
    (Tartu Ülikool, 2021) Mammadova, Sabina; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Tehnoloogiainstituut
    Delivery of macromolecular therapeutics, and specifically their endosomal escape is one of the challenges in the medicine. Although there are several delivery methods developed, there is still a need to overcome the challenges associated with endosomal entrapment. In this work HPV16 L2 protein and peptides derived from this protein were applied for in-creasing transfection efficacy of CPP mediated delivery of nucleic acid. For this, peptides derived from HPV L2 protein specific regions, that are responsible for L2 mediated endo-somal trafficking of viral DNA were tested. Both L2 protein and new synthesised peptides showed promising results for applying them as additives to the CPP/NA nanoparticles for therapeutic use and protein production in the future.