Browsing by Author "Mikhailova, Valentina"

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    Analysis of the docking interaction between Sld2 and Clb5 in budding yeast
    (Tartu Ülikool, 2021) Mikhailova, Valentina; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Tehnoloogiainstituut
    The cell cycle of Saccharomyces cerevisiae is governed by cyclin dependent kinases (Cdks), which are activated by periodically synthesized and degraded cyclins. The substrate target-ing by a cyclin-Cdk complex is mediated by the active site on the Cdk and the cyclin docking pocket. Docking interactions between short linear motifs (SLiMs) in target proteins and cy-clin-dependent kinases are shown to be critical regulators of different cell cycle events. SLiMs function in almost every pathway due to their role in regulatory function and signal transduction.