Browsing by Author "Rips, Karolin"

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    COVID-19 läbimurdeinfektsioonid ja neid mõjutavad tegurid
    (2022) Rips, Karolin; Fischer, Krista, juhendaja; Tartu Ülikool. Matemaatika ja statistika instituut; Tartu Ülikool. Loodus- ja täppisteaduste valdkond
    Bakalaureusetöö eesmärk on leida tegurid, mis mõjutavad COVID-19 vastu vaktsineeritute nakatumist ning vaktsineeritud nakatunute haiglaravi vajamist. Töö teoreetilises osas antakse ülevaade Eestis kasutatavatest COVID-19 vastastest vaktsiinidest ja logistilise regressiooni mudelist. Töö praktilises osas kirjeldatakse haiguse levikut, haiglaravi vajamist ja vaktsineeritust Eesti elanike seas. Seejärel hinnatakse logistilise regressiooni mudelid nakatumise ja haiglaravi vajamise kirjeldamiseks.
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    Geneetilise riskiskoori ja vaimse tervise häirete koosmõju südame-veresoonkonnahaiguste riskile
    (Tartu Ülikool, 2024) Rips, Karolin; Lehto, Kelli, juhendaja; Fischer, Krista, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Arvutiteaduse instituut
    Cardiovascular diseases (CVD) are the leading cause of death in Estonia. In order to avoid premature mortality, it is important to assess the risk of disease even before symptoms occur. For this purpose, risk models can be created that take into account the environmental factors influencing the risk of CVD and genetic predisposition. Associations between mental health disorders and CVD risk have also been found. The master’s thesis examines whether and how depression, bipolar disorder and anxiety disorders affect the risk of CVD and whether there is an interaction between the effects of these diseases and polygenic risk score (PRS) for coronary heart disease. Data from the Estonian Biobank and survival analysis methods are used to assess CVD risk. As a result, depression, anxiety disorder, and bipolar disorder increase the risk of CVD. Furthermore, a negative interaction between PRS and depression on CVD risk was found in women – depression significantly increases the risk of CVD, and there is no additional effect of PRS in the presence of depression (in other words, depression overshadows the effect of PRS).