Browsing by Author "Tooding, Liina-Mai"

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Association of the COMT Val108/158Met genotype with professional career and education: The Val-allele is more frequent in managers and in enterprising occupations
(ScienceDirect, 2018-01) Kurrikoff, Triin; Kaarma, Katrin; Tooding, Liina-Mai; Vaht, Mariliis; Tulviste, Tiia; Veidebaum, Toomas; Harro, Jaanus
Catechol-O-methyl transferase (COMT) is a key player in neurotransmission by catecholamines, and the functional COMT Val108/158Met polymorphism is strongly related to prefrontal reactivity and to dopamine levels. As dopamine is a critically important neurotransmitter in cognition, emotion and motivation, we addressed the potential impact of this genotype on life course by examining its association with being in enterprising professions. The parents (n = 1410) of the target subjects in the Estonian Children Personality Behaviour and Health Study reported their current occupation, and those classified as enterprising (n = 197; 18%) were compared with the remaining group. Additionally, the subjects self-classified themselves according to the International Standard Classification of Occupations and the group of managers (6.2%) was compared to other groups. We found that the COMT Val108/158Met Val/Val homozygotes were overrepresented among enterprising occupations and the Val-allele carriers among self-classified managers. While several measures associated with the Val/Val homozygosity were also associated with enterprising occupation, no simple path from the genotype to enterprising occupations emerged from structural equation models, suggesting that the COMT Val108/158Met genotype contributes to choices of profession via multiple interactive features. We also reproduced a previous finding that the COMT genotype is associated with educational attainment in a gender-dependent manner.
Muutuste analüüsi ja kommunikatsiooni töövahendi arendamine programmi Liikuma Kutsuv Kool jaoks
(Tartu Ülikool, 2018) Soolep, Carl-Ruuben; Vihalemm, Triin, juhendaja; Tooding, Liina-Mai; Tartu Ülikool. Sotsiaalteaduste valdkond; Tartu Ülikool. Ühiskonnateaduste instituut
Pilootuuring kutseõppeasutuste I kursuse õpilaste matemaatika teadmistest ja oskustest
(2003) Tooding, Liina-Mai; Rämson, Anne-Liis
Käesolevas analüüsis esitatakse üldülevaade 2003. aasta sügisel Eesti kutseõppeasutustes läbi viidud matemaatikateadmiste testi tulemustest. Et test koosnes põhikooli 2003. aasta matemaatikaeksami ülesannetest, siis on allpool võrdlusena kasutatud põhikooli lõpueksami tulemuste valikuuringu kokkuvõtlikke andmeid. Lisaks kutseõppeasutustele viidi test võrdluseesmärgil läbi ka väikeses gümnaasiumi 10. klassi õpilaste grupis.
Variants of the aggression-related RBFOX1 gene in a population representative birth cohort study: aggressiveness, personality and alcohol use disorder
(2020) Vaht, Mariliis; Laas, Kariina; Fernàndez-Castillo, Noèlia; Kurrikoff, Triin; Kanarik, Margus; Faraone, Stephen V.; Tooding, Liina-Mai; Veidebaum, Toomas; Franke, Barbara; Reif, Andreas; Cormand, Bru; Harro, Jaanus
Background Recently RBFOX1, a gene encoding an RNA binding protein, has consistently been associated with aggressive and antisocial behaviour. Several loci in the gene have been nominally associated with aggression in genome-wide association studies; the risk alleles being more frequent in general population. We have hence examined the association of four RBFOX1 single nucleotide polymorphisms, previously found related to aggressive traits, with aggressiveness, personality, and alcohol use disorder in birth cohort representative samples. Methods We used both birth cohorts of the Estonian Children Personality Behaviour and Health Study (ECPBHS; original n=1,238). Aggressiveness was assessed using the Buss-Perry Aggression Questionnaire and the Lifetime History of Aggressiveness structured interview at age 25 (younger cohort) or 33 (older cohort). Big Five personality at age 25 was measured with self reports and the lifetime occurrence of alcohol use disorder assessed with the MINI interview. RBFOX1 polymorphisms rs809682, rs8062784, rs12921846 and rs6500744 were genotyped in all participants. Given the restricted size of the sample, correction for multiple comparisons was not applied. Results Aggressiveness was not significantly associated with RBFOX1 genotype. RBFOX1 rs8062784 was associated with neuroticism and rs809682 with extraversion. Two out of four analyzed RBFOX1 variants, rs8062784, and rs12921846, were associated with occurrence of alcohol use disorder. Conclusions In the birth cohort representative sample of the ECPBHS, no association of RBFOX1 with aggressiveness was found, but RBFOX1 variants affected basic personality traits and the prevalence of alcohol use disorder. Future studies on RBFOX1 should consider the moderating role of personality and alcohol use patterns in aggressiveness.