(Tartu Ülikool, 2024) Nabeel, Muhammad; Rausalu, Kai, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Tehnoloogiainstituut
Adenoviruses, non-enveloped DNA viruses, pose a significant health concern. This study
explores the antiviral potential of four recombinant proteins with attached cationic
antimicrobial peptides (H1mod1R, H2mod2R, HELP and HIn) against the human adenovirus
(AdV-Gluc) in vitro. The proteins presented some antiviral activity, but this inhibitory effect
was independent of the concentrations of the proteins within the tested range. The results are
not aligned with the previous research on the cationic antimicrobial peptides with other
viruses. Currently, these proteins are not ideal for use as therapeutic against adenovirus, but
the good cytotoxicity profile suggests that further research is needed to optimize the efficacy
and to explore their mechanism of action for beneficial future applications.
