(Tartu Ülikool, 2021) Aid, Jana; Tõnissoo, Tambet, juhendaja; Hickey, Miriam Ann, juhendaja; Tartu Ülikool. Loodus- ja täppisteaduste valdkond; Tartu Ülikool. Molekulaar- ja rakubioloogia instituut
Alzheimer’s disease (AD) is a neurodegenerative disorder of the brain, that leads to cognitive
impairment. AD is characterised by the accumulation of β-amyloid peptides and tau proteins
into amyloid plaques and neurofibrillary tangles. AD currently has no cure, however promising
research and treatment is underway. The aim of this work is to determine appropriate endpoints
to use in a preclinical trial of 5xFAD mouse model of AD. In this thesis, I demonstrate endpoints
appropriate to use for preclinical trials and appropriate group and effect sizes.
