Driving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphism

dc.contributor.authorTokko, Tõnis
dc.contributor.authorEensoo, Diva
dc.contributor.authorMiškinyte, Grete
dc.contributor.authorHarro, Jaanus
dc.date.accessioned2023-02-21T13:17:42Z
dc.date.available2023-02-21T13:17:42Z
dc.date.issued2022
dc.description.abstractRoad traffic injuries are a leading cause of death for young adults, and young drivers with higher expression of symptoms of attention deficit-hyperactivity disorder (ADHD) could pose an even greater risk in traffic. Dopaminergic dysfunction has been found to occur in ADHD, with the dopamine transporter (DAT) gene VNTR polymorphism (DAT1 VNTR; rs28363170) being one of the most consistent genetic markers. Thus, we aimed at clarifying how the ADHD symptoms and the DAT1 VNTR relate to risk-taking behaviour in traffic, impulsivity and driving anger in young drivers. We used data of two traffic behaviour study samples (n = 741, mean age = 23.3±7.2 years; n = 995, mean age = 22.9±8.1 years) and the Estonian Children Personality Behaviour and Health Study (ECPBHS; traffic behaviour data n = 1016, mean age = 25.2±2.1 years). ADHD symptoms were assessed by self-report with the Adult ADHD Self-Report Scale (ASRS v1.1) and impulsivity with the Adaptive and Maladaptive Impulsivity Scale. Traffic behavioural measures were either self-reported (Driver Behaviour Questionnaire, Driving Anger Scale) or obtained from databases (registered accidents and violations). Drivers with more self-reported ADHD symptoms also reported more risk-taking in traffic and had more of recorded traffic accidents and violations. DAT1 9R carriers had a higher probability of high traffic risk behaviour only if they also had ADHD symptoms. Conclusion Higher level of ADHD symptoms is a significant risk factor in traffic, and carrying of the DAT1 9R allele appears to aggravate these risks.et
dc.identifier.urihttps://doi.org/10.1080/08039488.2022.2032330
dc.identifier.urihttp://hdl.handle.net/10062/89268
dc.language.isoenget
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/728018///Eat2beNICEet
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/667302///CoCA
dc.relation.ispartofseriesNordic Journal of Psychiatry;Volume 76, 2022 - Issue 8
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/*
dc.subjectADHDen
dc.subjectDAT1 VNTRen
dc.subjecttraffic behaviouren
dc.subjectimpulsivityen
dc.titleDriving risks of young drivers with symptoms of attention deficit hyperactivity disorder: association with the dopamine transporter gene VNTR polymorphismen
dc.typeinfo:eu-repo/semantics/articleet

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