Ovarian Physiology and GWAS: Biobanks, Biology, and Beyond

Lühendatud kirje lehekülg
dc.contributor"European Union (EU)" and "Horizon 2020"
dc.contributor.authorLaisk-Podar, Triin
dc.contributor.authorLindgren, Cecilia M.
dc.contributor.authorPeters, Maire
dc.contributor.authorTapanainen, Juha S.
dc.contributor.authorLambalk, Cornelis B.
dc.contributor.authorSalumets, Andres
dc.contributor.authorMägi, Reedik
dc.date.accessioned2019-02-26T11:05:17Z
dc.date.available2019-02-26T11:05:17Z
dc.date.issued2016-05
dc.description.abstractOvarian function is central to female fertility, and several genome-wide association studies (GWAS) have been carried out to elucidate the genetic background of traits and disorders that reflect and affect ovarian physiology. While GWAS have been successful in reporting numerous genetic associations and highlighting involved pathways relevant to reproductive aging, for ovarian disorders, such as premature ovarian insufficiency and polycystic ovary syndrome, research has lagged behind due to insufficient study sample size. Novel approaches to study design and analysis methods that help to fit GWAS findings into biological context will improve our knowledge about genetics governing ovarian function in fertility and disease, and provide input for clinical tools and better patient management.et
dc.identifier.urihttps://doi.org/10.1016/j.tem.2016.04.011
dc.identifier.urihttp://hdl.handle.net/10062/63403
dc.language.isoenget
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/692065///WIDENLIFEet
dc.relation.ispartofseriesTrends in endocrinology and metabolism;TEM. 27 (7), 516−528
dc.rightsinfo:eu-repo/semantics/openAccesset
dc.subjectovarian reserveet
dc.subjectmenopauseet
dc.subjectpolycystic ovary syndromeet
dc.subjectpremature ovarian insufficiencyet
dc.titleOvarian Physiology and GWAS: Biobanks, Biology, and Beyondet
dc.typeinfo:eu-repo/semantics/articleet

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