The role of the serotonin transporter and 5-HT1A receptor genes promoter polymorphisms 5-HTTLPR and C(-1019)G in impulsivity and traffic violations

Abstract

This papers purpose was to use appropriate statistical tests to pinpoint the relationships between impulsivity with its adaptive and maladaptive facets, two serotonergic system gene promoter polymorphisms - 5-HTTLPR and C(-1019)G, and different traffic violations and accidents. The sample was the sum of two previous study samples from 2007 and 2014 (n = 2113). The study found that traffic violators were higher in adaptive impulsivity and that 5-HTTPLR La/La homozygotes were more likely traffic violators. A polymorphic interaction of 5-HTTLPR+C(-1019)G showed that contrary to the hypotheses, La/La+G/G genotype carriers were more likely to speed while S allele+C/C genotype carriers were least likely to violate traffic law which may point to an interactive effect on the desensitization of 5-HT1a autoreceptors.