The N-terminus of Melanoma-associated antigen A10 interacts with peripheral nucleoporins

Abstract

Showing common features of tumorigenesis, Melanoma-associated antigen A10 (MAGEA10) possesses the potential for cancer therapy. MAGEA10 is a highly immunogenic MAGEA family member that acts as a hub protein and is associated with global hypomethylation. The N-terminus of MAGEA10 is involved in its expression, nuclear transport, and electrophoretic mobility shift. This thesis aims to characterise further the N-terminus of MAGEA10 and find its potential interaction partners.